Just experienced this problem on ONE of our three DC's. (start of march 2022)
Took me several days to find this post, which turned out to be the exact same problem.
I have to assume, since your posts are from september 2021 describing the error as being only there for a few days before Microsoft fixed it; that Microsoft made the same error once again.
I was unable to reinstall .net as it was already installed.
But I could run REPAIR using the /uninstall switch on the installer.
- However, this problem did not get fixed, as the installer ONLY recreates the latest version regkey.
- That means that any program dependent on an earlier version of .net, cannot run.
I was unable to run "Programs and Features" under APPS, as it is, as you may have guessed, dependent on a very early version of .net.
Now, Microsoft COULD make it much easier to fix this problem by letting the REPAIR function of the .net installer recreate ALL previous versions worth of redirects in the registry, not just the newest version.
Also, a catchall for problems pertaining to programs dependent on older versions; if a program is dependent on an older version and the registry has no knowledge (see missing .reg below), run a check if a newer .net is incorrectly installed (look for other clues to its existence). If so, then ask to run a repair on .net, don't just try a new download.
To fix the problem, I had to manually import regkeys copied from my workstation.
Instant fix. Could start programs after that, but did restart the DC anyway, just to make sure all dependencies would start up.
---
Windows Registry Editor Version 5.00
[HKEY_LOCAL_MACHINE\SOFTWARE\WOW6432Node\Microsoft\.NETFramework\v4.0.30319]
"AspNetEnforceViewStateMac"=dword:00000001
[HKEY_LOCAL_MACHINE\SOFTWARE\WOW6432Node\Microsoft\.NETFramework\v4.0.30319\SKUs]
[HKEY_LOCAL_MACHINE\SOFTWARE\WOW6432Node\Microsoft\.NETFramework\v4.0.30319\SKUs\.NETFramework,Version=v4.0]
[HKEY_LOCAL_MACHINE\SOFTWARE\WOW6432Node\Microsoft\.NETFramework\v4.0.30319\SKUs\.NETFramework,Version=v4.0,Profile=Client]
[HKEY_LOCAL_MACHINE\SOFTWARE\WOW6432Node\Microsoft\.NETFramework\v4.0.30319\SKUs\.NETFramework,Version=v4.0.1]
[HKEY_LOCAL_MACHINE\SOFTWARE\WOW6432Node\Microsoft\.NETFramework\v4.0.30319\SKUs\.NETFramework,Version=v4.0.1,Profile=Client]
[HKEY_LOCAL_MACHINE\SOFTWARE\WOW6432Node\Microsoft\.NETFramework\v4.0.30319\SKUs\.NETFramework,Version=v4.0.2]
[HKEY_LOCAL_MACHINE\SOFTWARE\WOW6432Node\Microsoft\.NETFramework\v4.0.30319\SKUs\.NETFramework,Version=v4.0.2,Profile=Client]
[HKEY_LOCAL_MACHINE\SOFTWARE\WOW6432Node\Microsoft\.NETFramework\v4.0.30319\SKUs\.NETFramework,Version=v4.0.3]
[HKEY_LOCAL_MACHINE\SOFTWARE\WOW6432Node\Microsoft\.NETFramework\v4.0.30319\SKUs\.NETFramework,Version=v4.0.3,Profile=Client]
[HKEY_LOCAL_MACHINE\SOFTWARE\WOW6432Node\Microsoft\.NETFramework\v4.0.30319\SKUs\.NETFramework,Version=v4.5]
[HKEY_LOCAL_MACHINE\SOFTWARE\WOW6432Node\Microsoft\.NETFramework\v4.0.30319\SKUs\.NETFramework,Version=v4.5.1]
[HKEY_LOCAL_MACHINE\SOFTWARE\WOW6432Node\Microsoft\.NETFramework\v4.0.30319\SKUs\.NETFramework,Version=v4.5.2]
[HKEY_LOCAL_MACHINE\SOFTWARE\WOW6432Node\Microsoft\.NETFramework\v4.0.30319\SKUs\.NETFramework,Version=v4.5.3]
[HKEY_LOCAL_MACHINE\SOFTWARE\WOW6432Node\Microsoft\.NETFramework\v4.0.30319\SKUs\.NETFramework,Version=v4.6]
[HKEY_LOCAL_MACHINE\SOFTWARE\WOW6432Node\Microsoft\.NETFramework\v4.0.30319\SKUs\.NETFramework,Version=v4.6.1]
[HKEY_LOCAL_MACHINE\SOFTWARE\WOW6432Node\Microsoft\.NETFramework\v4.0.30319\SKUs\.NETFramework,Version=v4.6.2]
[HKEY_LOCAL_MACHINE\SOFTWARE\WOW6432Node\Microsoft\.NETFramework\v4.0.30319\SKUs\.NETFramework,Version=v4.7]
[HKEY_LOCAL_MACHINE\SOFTWARE\WOW6432Node\Microsoft\.NETFramework\v4.0.30319\SKUs\.NETFramework,Version=v4.7.1]
[HKEY_LOCAL_MACHINE\SOFTWARE\WOW6432Node\Microsoft\.NETFramework\v4.0.30319\SKUs\.NETFramework,Version=v4.7.2]
[HKEY_LOCAL_MACHINE\SOFTWARE\WOW6432Node\Microsoft\.NETFramework\v4.0.30319\SKUs\.NETFramework,Version=v4.8]
[HKEY_LOCAL_MACHINE\SOFTWARE\WOW6432Node\Microsoft\.NETFramework\v4.0.30319\SKUs\Client]
[HKEY_LOCAL_MACHINE\SOFTWARE\WOW6432Node\Microsoft\.NETFramework\v4.0.30319\SKUs\Default]
[HKEY_LOCAL_MACHINE\SOFTWARE\Microsoft\.NETFramework\v4.0.30319]
"AspNetEnforceViewStateMac"=dword:00000001
[HKEY_LOCAL_MACHINE\SOFTWARE\Microsoft\.NETFramework\v4.0.30319\SKUs]
[HKEY_LOCAL_MACHINE\SOFTWARE\Microsoft\.NETFramework\v4.0.30319\SKUs\.NETFramework,Version=v4.0]
[HKEY_LOCAL_MACHINE\SOFTWARE\Microsoft\.NETFramework\v4.0.30319\SKUs\.NETFramework,Version=v4.0,Profile=Client]
[HKEY_LOCAL_MACHINE\SOFTWARE\Microsoft\.NETFramework\v4.0.30319\SKUs\.NETFramework,Version=v4.0.1]
[HKEY_LOCAL_MACHINE\SOFTWARE\Microsoft\.NETFramework\v4.0.30319\SKUs\.NETFramework,Version=v4.0.1,Profile=Client]
[HKEY_LOCAL_MACHINE\SOFTWARE\Microsoft\.NETFramework\v4.0.30319\SKUs\.NETFramework,Version=v4.0.2]
[HKEY_LOCAL_MACHINE\SOFTWARE\Microsoft\.NETFramework\v4.0.30319\SKUs\.NETFramework,Version=v4.0.2,Profile=Client]
[HKEY_LOCAL_MACHINE\SOFTWARE\Microsoft\.NETFramework\v4.0.30319\SKUs\.NETFramework,Version=v4.0.3]
[HKEY_LOCAL_MACHINE\SOFTWARE\Microsoft\.NETFramework\v4.0.30319\SKUs\.NETFramework,Version=v4.0.3,Profile=Client]
[HKEY_LOCAL_MACHINE\SOFTWARE\Microsoft\.NETFramework\v4.0.30319\SKUs\.NETFramework,Version=v4.5]
[HKEY_LOCAL_MACHINE\SOFTWARE\Microsoft\.NETFramework\v4.0.30319\SKUs\.NETFramework,Version=v4.5.1]
[HKEY_LOCAL_MACHINE\SOFTWARE\Microsoft\.NETFramework\v4.0.30319\SKUs\.NETFramework,Version=v4.5.2]
[HKEY_LOCAL_MACHINE\SOFTWARE\Microsoft\.NETFramework\v4.0.30319\SKUs\.NETFramework,Version=v4.5.3]
[HKEY_LOCAL_MACHINE\SOFTWARE\Microsoft\.NETFramework\v4.0.30319\SKUs\.NETFramework,Version=v4.6]
[HKEY_LOCAL_MACHINE\SOFTWARE\Microsoft\.NETFramework\v4.0.30319\SKUs\.NETFramework,Version=v4.6.1]
[HKEY_LOCAL_MACHINE\SOFTWARE\Microsoft\.NETFramework\v4.0.30319\SKUs\.NETFramework,Version=v4.6.2]
[HKEY_LOCAL_MACHINE\SOFTWARE\Microsoft\.NETFramework\v4.0.30319\SKUs\.NETFramework,Version=v4.7]
[HKEY_LOCAL_MACHINE\SOFTWARE\Microsoft\.NETFramework\v4.0.30319\SKUs\.NETFramework,Version=v4.7.1]
[HKEY_LOCAL_MACHINE\SOFTWARE\Microsoft\.NETFramework\v4.0.30319\SKUs\.NETFramework,Version=v4.7.2]
[HKEY_LOCAL_MACHINE\SOFTWARE\Microsoft\.NETFramework\v4.0.30319\SKUs\.NETFramework,Version=v4.8]
[HKEY_LOCAL_MACHINE\SOFTWARE\Microsoft\.NETFramework\v4.0.30319\SKUs\Client]
[HKEY_LOCAL_MACHINE\SOFTWARE\Microsoft\.NETFramework\v4.0.30319\SKUs\Default]
---
Hope this helps any other poor soul who stumbles onto this post.